Avi Kumar

Avighnash · अविघ्नाश · “remover of obstacles”

Co-Founder & CEO of Neocore Health, Inc.

Fighting for accessible, proactive, and longitudinal healthcare. I've spent the last 4 years building at the cutting edge of cognitive and sensory therapeutics. There are 3 billion people that can be helped, and my dream is to reach every single one of them.

Interests

I'm interested in a lot of things, primarily the intersection of neuroscience, biology, computation, and healthcare. The systems behind human intelligence, neuropsychiatry and its social impacts, and how we can build artificial life (chimeroids, assembloids).

I've read basically every dystopian book/series. I like thrifting and action-comedy movies. Favorite book series: Harry Potter, The Hunger Games, and The Unwanteds. Favorite movie: Spy. Favorite band: Snow Strippers.

Strong opinions

Accomplishments

I've built and worked on apps that have helped millions of users.

I submitted Neocore Health's CMS comment on clinically integrated, longitudinal therapeutic care. This work also helped Mark McClellan's group at Duke-Margolis; he's a former FDA commissioner and CMS administrator.

What I've been reading

MonthTitle
Digital Twins for Just-in-Time Adaptive Interventions (JITAIs): Framework for Optimizing and Continually Improving JITAIs
Commentary on Capitation
The Future of Intervention Science: Process-Based Therapy
On the Nature of the Swarm
Effects of Sodium Thiosulfate Versus Observation on Development of Cisplatin-Induced Hearing Loss in Children With Cancer (ACCL0431)
Effectiveness of Just-in-Time Adaptive Interventions for Improving Mental Health and Psychological Well-Being: A Systematic Review and Meta-Analysis
A new generation of patient-reported outcome measures with large language models
Internet-Based Audiologist-Guided Cognitive Behavioral Therapy for Tinnitus: Randomized Controlled Trial
Can We Predict Who Will Benefit From Cognitive-Behavioural Therapy? A Systematic Review and Meta-Analysis of Machine Learning Studies
Leveraging large language models in patient-reported outcome measure development: practical opportunities, cautions, and a human-in-the-loop roadmap
Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and Hyperacusis Rehabilitation: Outcomes for Patients Treated in Routine Practice
Conversation as Measurement in Clinical Encounters: Observable Phase Structure, Partially Observable Patient State
Insomnia: Conceptual Issues in the Development, Persistence, and Treatment of Sleep Disorder in Adults
Cognitive Behavioral Therapy for Misophonia: A Randomized Clinical Trial
Human brain organoids record the passage of time over multiple years
Tinnitus. I: Auditory Mechanisms: A Model for Tinnitus and Hearing Impairment
Systematic Review and Meta-Analysis of the Correlation Between Tinnitus and Mental Health
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
A Randomised Controlled Dismantling Trial of Sleep Restriction Therapies for Chronic Insomnia Disorder in Middle Childhood: Effects on Sleep and Anxiety, and Possible Contraindications
Reliability of human cortical organoid generation
Hidden Hearing Injury: The Emerging Science and Military Relevance of Cochlear Synaptopathy
Maximizing Exposure Therapy: An Inhibitory Learning Approach
Efficacy of an Internet-Delivered Intervention for Improving Insomnia Severity and Functioning in Veterans: Randomized Controlled Trial
Controlling Risk in Capitation Payment: Multivariate Definitions of Risk Groups
Comparative Effectiveness and User-Rated Helpfulness of Digital Just-in-Time Adaptive Interventions for Psychological Distress
Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial
Cisplatin-Induced Hearing Loss Prevention With Intratympanic Therapy: Systematic Review and Meta-Analysis
Effectiveness of Guided Internet-Based Cognitive Behavioral Therapy vs Face-to-Face Clinical Care for Treatment of Tinnitus: A Randomized Clinical Trial
Components and Delivery Formats of Cognitive Behavioral Therapy for Chronic Insomnia in Adults: A Systematic Review and Component Network Meta-Analysis
Commentary: Consensus Definition of Misophonia
Just-in-Time Adaptive Interventions (JITAIs) in Mobile Health: Key Components and Design Principles for Ongoing Health Behavior Support
Improving Mental Health Services: A 50-Year Journey from Randomized Experiments to Artificial Intelligence and Precision Mental Health
Early Detection of Blast-Induced Hidden Hearing Loss in Military Personnel Using an Extended Audiological Battery
Control theory: a useful conceptual framework for personality-social, clinical, and health psychology
The Effects of Digital Cognitive Behavioral Therapy for Insomnia on Cognitive Function: A Randomized Controlled Trial
Bill Patients for Emailing? This Could Backfire
The ‘What’ and ‘Why’ of Goal Pursuits: Human Needs and the Self-Determination of Behavior
Intersection of nanomaterials and organoids technology in biomedicine
Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmark
Active Duty Service Members, Primary Managers, and Administrators’ Perspectives on a Novel Sleep Telehealth Management Platform in the U.S. Military Healthcare System
Neocore Health — Protecting Program Integrity While Enabling Clinically Integrated Longitudinal Therapeutic Care
Population Simulation at the Replication Floor
Michael Grandner — CY 2027 Physician Fee Schedule Comment on Sleep Care, Digital CBT-I, and Remote Therapeutic Monitoring
Using Computational Models of Learning to Advance Cognitive Behavioral Therapy
Risk Adjustment and Medicare: Taking a Closer Look
CMS Public Comment — CMS-2025-1393-32726
MedPAC — Comments on the CY 2027 Medicare Physician Fee Schedule Proposed Rule
Thea Blystone — Comments Regarding Proposed Changes to Remote Physiologic Monitoring and Remote Therapeutic Monitoring
Laura Martinmaas — 2027 CMS Proposed Changes
Just-in-Time Adaptive Interventions: Where Are We Now and What Is Next?
Blast-Related Ear Injuries Among U.S. Military Personnel
CMS — LEAD (Long-term Enhanced ACO Design) Model
Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss (ACHIEVE): a multicentre, randomised, controlled trial in the United States
Why a Planned Reorganization of the FDA Creates Major Challenges
Duke-Margolis Institute — Comments on the CY 2027 Medicare Physician Fee Schedule Proposed Rule
What the Future Holds: Machine Learning to Predict Success in Psychotherapy
Care Transitions and Value-Based Payment Models in the United States
Internet-Delivered Cognitive-Behavior Therapy for Tinnitus: A Randomized Controlled Trial
CMS Public Comment — CMS-2026-1916-0834
CMS Public Comment — CMS-2026-2344-2115
CMS Public Comment — CMS-2026-2080-0209
Assessing Cognitive Processes Related to Insomnia: A Review and Measurement Guide for Harvey's Cognitive Model for the Maintenance of Insomnia
CMS — ACCESS for Primary Care Providers and Referring Clinicians
Cognitive Behavioral Therapy for Alleviating the Distress Caused by Tinnitus, Hyperacusis and Misophonia: Current Perspectives
CMS Adds Medicare Options to Help People Manage Substance Use Disorder, Heart Failure, and Other Common Chronic Conditions
CMS Announces Expansion of ACCESS Model
Artificial Intelligence Can Be Regulated Using Current Patient Safety Procedures and Infrastructure in Hospitals
Neurophysiological Approach to Tinnitus Patients
An Effective Treatment for Tinnitus and Hyperacusis Based on Cognitive Behavioral Therapy in an Inpatient Setting: A 10-Year Retrospective Outcome Analysis
Long-Term Outcomes of an Internet-Based Cognitive Behavior Therapy Intervention for Tinnitus: Follow-Up Analysis of a Nonrandomized Clinical Trial
Treatment of Youth Misophonia: A Randomized Controlled Trial Comparing Transdiagnostic Cognitive-Behavioral Therapy to Psychoeducation and Relaxation Training
Maximizing Cochlear Implant Outcomes with Short-Term Aural Rehabilitation
Concept and implementation of an adaptive digital hearing training system for cochlear implant aftercare
Maximizing the Efficacy of Interoceptive Exposure by Optimizing Inhibitory Learning: A Randomized Controlled Trial
An LLM-supported just-in-time adaptive intervention delivered by a socially assistive robot for cognitive training in mild cognitive impairment: study protocol for an assessor-blinded randomized controlled trial
Incorporating an Intelligent Tutoring System Into a Game-Based Auditory Rehabilitation Training for Adult Cochlear Implant Recipients: Algorithm Development and Validation
CMS May Upend Remote Patient Monitoring. Here’s What to Know
Hearing Intervention, Social Isolation, and Loneliness: A Secondary Analysis of the ACHIEVE Randomized Clinical Trial
Updated Guidance for Author Use of AI in Medical Publication
Developing Innovation Models
Optimizing Inhibitory Learning During Exposure Therapy
FDA Chief Moves On
Public Comments
Sensory Coding and Cognitive Processing of Sound in Veterans With Blast Exposure
ACCESS (Advancing Chronic Care with Effective, Scalable Solutions) Model
Medicaid Work Requirements Rule Could Affect Access to Hearing Healthcare
Personalized Interventions for Behaviour Change: A Scoping Review of Just-in-Time Adaptive Interventions
Stages of change in adults with acquired hearing impairment seeking help for the first time: application of the transtheoretical model in audiologic rehabilitation
New Partnership: From Spring Reflections to Summer Health
Building Our Care Coordinator Agent
Using Risk Assessment to Evaluate Adverse Selection Under Capitated Contracts
MindGuard: Open-Source Guardrails That Understand Clinical Context
Network Meta-Analysis Examining Efficacy of Components of Cognitive Behavioural Therapy for Insomnia
Arbor: A Framework for Reliable Navigation of Critical Conversation Flows
Large Language Models for Mental Health Diagnostic Assessments: Exploring The Potential of Large Language Models for Assisting with Mental Health Diagnostic Assessments — The Depression and Anxiety Case.
Cerebral organoids model human brain development and microcephaly.
A Randomized Controlled Trial to Test the Efficacy of Trans-Tympanic Injections of a Sodium Thiosulfate Gel to Prevent Cisplatin-Induced Ototoxicity in Patients With Head and Neck Cancer
Cell diversity and network dynamics in photosensitive human brain organoids
Treatment Selection in Depression
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells
Maturation and circuit integration of transplanted human cortical organoids
In vitro neurons learn and exhibit sentience when embodied in a simulated game-world
Real-time computing without stable states: a new framework for neural computation based on perturbations
Response: Commentary: The Brain Basis for Misophonia
Just-in-Time Adaptive Interventions for Physical Activity: A Systematic Review of Their Public Health Impact and Methodological Quality
Why brain organoids are not conscious yet
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
An epigenetic barrier sets the timing of human neuronal maturation
The Effectiveness of Digital Cognitive Behavioral Therapy to Treat Insomnia Disorder in US Adults: Nationwide Decentralized Randomized Controlled Trial
Suicidal Ideation and Behaviors in Adults With Tinnitus: A Systematic Review and Meta-Analysis
Digital Cognitive Behavioral Therapy for Insomnia for People With Comorbid Psychological Distress: A Large Scale Randomized Controlled Trial
Effects of Internet-based and mobile device-based cognitive behavioral therapy on tinnitus intervention: a systematic review and meta-analysis
Effectiveness of a Digital Clinical Decision Support Platform to Augment CBTI Capability Gaps in the DHA/DoD.
Using engineering control principles to inform the design of adaptive interventions: a conceptual introduction
On the Reliability of Psychological Scales on Large Language Models.
ProKnow: Process Knowledge for Safety Constrained and Explainable Question Generation for Mental Health Diagnostic Assistance.
Hospital Outpatient PPS
Audiology Services
Measuring Adverse Selection in Managed Health Care
ASHA — Comments to CMS on the CY 2023 Medicare Physician Fee Schedule Proposed Rule
CBT and the Future of Personalized Treatment: A Proposal
American Academy of Audiology — Comments on the CY 2026 Medicare Physician Fee Schedule Proposed Rule
Speech-Language Pathology CPT and HCPCS Code Changes for 2026
Tinnitus, Depression, Anxiety, and Suicide in Recent Veterans: A Retrospective Analysis
Adapting Just-in-Time Interventions to Vulnerability and Receptivity: Conceptual and Methodological Considerations
Conversational AI should fill the white space in mental health care, not replace humans
Features, Functionality, and Acceptability of Internet-Based Cognitive Behavioral Therapy for Tinnitus in the United States
Randomized Controlled Trial in Clinical Settings to Evaluate Effectiveness of Coping Skills Education Used With Progressive Tinnitus Management
Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT)
Personalized Treatment Selection in Routine Care: Integrating Machine Learning and Statistical Algorithms to Recommend Cognitive Behavioral or Psychodynamic Therapy
Randomized Trial of a Generative AI Chatbot for Mental Health Treatment
Multi-Region Brain Organoid –Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components
The Effectiveness of Unguided Internet-Based Cognitive Behavioral Therapy for Tinnitus for Patients With Tinnitus Alone or Combined With Hyperacusis and/or Misophonia: A Preliminary Analysis
Assembloid Agency: Unreal Engine API for Brain-on-a-Chip Platforms
Mediators of Cognitive Therapy and Behavior Therapy for Insomnia Disorder: A Test of the Processes in the Cognitive Model
In Patients Undergoing Cochlear Implantation, Psychological Burden Affects Tinnitus and the Overall Outcome of Auditory Rehabilitation
The Brain Basis for Misophonia
The efficacy of maxillary protraction protocols with the micro-implant-assisted rapid palatal expander (MARPE) and the novel N2 mini-implant—a finite element study
Specialised Treatment Based on Cognitive Behaviour Therapy Versus Usual Care for Tinnitus: A Randomised Controlled Trial
Perceived Barriers and Facilitators to App Use in Australian Audiology Clinics
Tutorial for Using Control Systems Engineering to Optimize Adaptive Mobile Health Interventions
Blast Exposure, Tinnitus, Hearing Loss, and Postdeployment Quality of Life in U.S. Veterans: A Longitudinal Analysis
Systematic review and meta-analysis of adverse events in clinical trials of mental health apps
Exposure Therapy Augmentation: A Review and Extension of Techniques Informed by an Inhibitory Learning Approach
Treatment of tinnitus in the elderly: a controlled trial of cognitive behavior therapy
Relationship Between Tinnitus and Hearing Outcomes Among US Military Personnel After Blast Injury
Psychological aspects of tinnitus and the application of cognitive-behavioral therapy
Development and Evaluation of HopeBot: an LLM-based chatbot for structured and interactive PHQ-9 depression screening.
A Network Theory of Mental Disorders
Large Language Models for Psychological Assessment: A Comprehensive Overview
Methods of Reducing the Financial Risk of Physicians Under Capitation
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Efficacy of Contextually Tailored Suggestions for Physical Activity: A Micro-randomized Optimization Trial of HeartSteps
Assembly of functionally integrated human forebrain spheroids
Transtympanic Sodium Thiosulfate for Prevention of Cisplatin-Induced Ototoxicity: A Randomized Clinical Trial
Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment
The Case Against Organoid Consciousness.
Predicting Depression Treatment Outcomes for Cognitive Behavioural Therapy Using Machine Learning: A Systematic Review and Meta-Analysis
Long-term maturation of human cortical organoids matches key early postnatal transitions
Combined Cognitive Behavioral Therapy and Sound Therapy for Chronic Tinnitus: A Systematic Review and Meta-Analysis
The Implementation and Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Primary Care: A Pilot Study
The behavioral intervention technology model: an integrated conceptual and technological framework for eHealth and mHealth interventions
Comparative Effectiveness and Predictors of Cognitive Behavioral Therapy for Insomnia and Its Components in Older Adults: Main Outcomes of a Randomized Dismantling Trial
Suicidal Ideation in People With Tinnitus: A Systematic Review and Meta-Analysis
The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions
Microrandomized trials: An experimental design for developing just-in-time adaptive interventions
A Randomized Controlled Trial Comparing Guided Internet-Based Multi-Component Treatment and Internet-Based Guided Sleep Restriction Treatment to Care as Usual in Insomnia
The multiphase optimization strategy (MOST) and the sequential multiple assignment randomized trial (SMART): new methods for more potent eHealth interventions
Characterization of Acute Hearing Changes in United States Military Populations
Exploring the Assistance Dilemma in Experiments with Cognitive Tutors.
We need minimally disruptive medicine
Post-surgical complications of supernumerary teeth in the mandibular premolar area: A systematic review
Conversational AI for Automated Patient Questionnaire Completion: Development Insights and Design Principles.
Advances in Cognitive Theory and Therapy: The Generic Cognitive Model
How Does Risk Selection Respond to Risk Adjustment? New Evidence from the Medicare Advantage Program
Artificial intelligence and the future of patient-centered outcomes
Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss
Beyond the Current State of Just-in-Time Adaptive Interventions in Mental Health: A Qualitative Systematic Review
Are LLMs effective psychological assessors? Leveraging adaptive RAG for interpretable mental health screening through psychometric practice.
Telephone-Based Progressive Tinnitus Management for Persons With and Without Traumatic Brain Injury: A Randomized Controlled Trial
Applying Precision Methods to Treatment Selection for Moderate/Severe Depression in Person-Centered Experiential Therapy or Cognitive Behavioral Therapy
Beyond rating scales: With targeted evaluation, large language models are poised for psychological assessment
The rise of three-dimensional human brain cultures
Cognitive Behaviour Therapy for Hyperacusis: A Randomized Controlled Trial
A Cognitive Model of Insomnia
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development
Generation of Functional Human 3D Cortico-Motor Assembloids
Tinnitus-Related Fear: Mediating the Effects of a Cognitive Behavioural Specialised Tinnitus Treatment
Consensus Definition of Misophonia: A Delphi Study
Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish.
Is Digital Cognitive Behavioural Therapy for Insomnia Effective in Treating Sub-Threshold Insomnia: A Pilot RCT
Thoughts About Suicide and Self-Harm in Patients With Tinnitus and Hyperacusis
Brain organoid reservoir computing for artificial intelligence.
Impact of Low-Level Blast Exposure From Military Training and Career Cumulation on Hearing Outcomes
The Network Approach to Psychopathology: A Review of the Literature 2008–2018 and an Agenda for Future Research
Human assembloid model of the ascending neural sensory pathway
Neuronal avalanches in neocortical circuits
Assessment and Disruption of Ruminative Episodes to Enhance Mobile Cognitive Behavioral Therapy Just-in-Time Adaptive Interventions in Clinical Depression: Pilot Randomized Controlled Trial
Protective Effects of Sodium Thiosulfate for Cisplatin-Mediated Ototoxicity in Patients With Head and Neck Cancer
The free-energy principle: a unified brain theory?
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
The History, Current Status, and Possible Future of Precision Mental Health
Cognitive Behavioural Therapy (CBT) for Managing Tinnitus, Hyperacusis, and Misophonia: The 2025 Tonndorf Lecture
Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output
Isolating the Role of Time in Bed Restriction in the Treatment of Insomnia: A Randomized, Controlled, Dismantling Trial Comparing Sleep Restriction Therapy With Time in Bed Regularization
Tinnitus and Its Association With Mental Health and Health-Related Quality of Life in an Older Population: A Nationwide Cross-Sectional Study
A Pilot Randomized Controlled Trial of the Insomnia Coach Mobile App to Assess Its Feasibility, Acceptability, and Potential Efficacy
Blast-Induced Hearing Loss
Insomniacs' Reported Use of CBT Components and Relationship to Long-Term Clinical Outcome
Large Language Model Psychometrics: A Systematic Review of Evaluation, Validation, and Enhancement
Clinical outcomes and reporting quality of large language model interventions in practice: a systematic evidence map

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